Indiana University
School of Optometry

Case 1: The Case of the Enlarging Spot

THE PARLOR . . .
The answer revealed: Amelanotic Iris Melanoma

Pathology revealed spindle cell morphology (relatively non-aggressive). Systemic work-up revealed no sign of metastases.

Iris melanomas (seen most frequently in blue irides) account for only a small portion of uveal tumors (<10%). They are inferiorly located due to sun exposure and may distort the pupil. Iris melanomas rarely metastasize (3-5%) because visibility typically leads to early detection. Satellite lesions can be seen. Increased IOP is common with seeding of tumor cells into the trabecular meshwork.

Differential diagnoses include iris nevi, Lisch nodules, Koeppe and Busacca nodules.




Another iris melanoma

Angle with OCT (not Visante)


Iris bombe with OCT


Angle in PDS

Sector iridectomy performed for complete resection.

case 1 eye post-op Postoperative. Notice the cortical cataract secondary to longstanding pressure on the lens.



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URL: http://www.opt.indiana.edu/ce/mystery/parlor01.htm
Revised: July 21, 2008

IU Optometry home page: http://www.opt.indiana.edu/
Comments (content): Dr. Brad Sutton
Comments: Web Administrator
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