IU School of Optometry Continuing Education
Differential Diagnosis and Management of Viral Keratoconjunctivitis

Simplified Differential Diagnosis of Viral Eye Disease

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Blepharitis

  • Etiology: Staphylococcus
  • Bilateral
  • History of recurrent hordeoli
  • Collarettes, madarosis
  • Inferior corneal pannus
  • Dry eye
  • Marginal infiltrates, ulcers, phylectenules, old scars

Chicken Pox

  • Etiology: Varicella
  • Typically childhood presentation
  • Bilateral ocular involvement with scalp and trunk vesicles
  • Papillary conjunctivitis and lid lesions
  • Treatment: Supportive

Resolving Corneal Abrasions

  • History of trauma
  • Foreign body sensation to severe pain
  • Unilateral
  • Healing pattern in a pseudo-dendritic pattern
  • Treatment: Antibiotic, cycloplegic, +/-bandage lens

Recurrent Epithelial Erosions

  • Morning pain
  • Possible past history of trauma
  • Unilateral
  • Intrapalpebral location common
  • Underlying anterior basement membrane dystrophies
  • Treatment: Similar to corneal abrasion with the addition of hypertonic solution or ointment. Consider superficial keratectomy in recurrent cases.

Inclusion Conjunctivitis

  • Etiology: Chlamydia
  • Young, sexually active adults
  • Mucopurulent discharge
  • Micropannus, subepithelial infiltrates, punctate keratitis
  • Predominantly a follicular conjunctivitis
  • May involve limbus
  • Culture positive
  • Treatment: 1gm dose Azythromycin

Thygeson Keratitis

  • White eye with foreign body sensation, photophobia, and tearing
  • Bilateral but asymmetric
  • Random punctate keratitis with subepithelial opacities
  • No conjunctivitis
  • Recurrent
  • Treatment: topical steroid

Epithelial Splits Secondary to Soft Contact Lenses

  • Soft contact lens wearer
  • Few symptoms: Minor irritation, injection
  • Unilateral
  • Superior cornea, circumferential linear lesion
  • Treatment: Remove and refit contact lens

Acanthamoeba Keratitis

  • Contact lens wearer
  • Poor contact lens hygiene
  • Acute with rapid progression: severe pain, decreased vision
  • Varied stellate or dendriform epithelial and subepithelial irregularities
  • Disciform edema, ring-shaped stromal infiltrate
  • 70%-80% originally diagnosed as herpetic infection
  • Treatment: referral to corneal subspecialist
  • Principal Management
    • Antimicrobial therapy
    • Topical steroids
    • Topical cycloplegics: 5% homatropine
    • Control pain with oral nonsteroidal anti-inflammatory agents
    • Penetrating keratoplasty


Go to: Viral Keratoconjunctivitis CE table of contents


URL: http://www.opt.indiana.edu/ce/virker/ddx.htm
Revised: November 28, 2005
IU Optometry home page: http://www.opt.indiana.edu/
Comments (content): Dr. Vic Malinovsky at malinovs@indiana.edu or Dr. Jane Ann Grogg at jgrogg@indiana.edu
Comments: Web Administrator
Page design and coding: Terri Greene
Copyright © 2005, The Trustees of Indiana University