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Angle on Glaucoma: Medications
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Xalatan ®

Generic name: latanaprost
Concentration: 0.005%
Mechanism of action: This prostaglandin analog enhances aqueous humor outflow, thus lowering the pressure in the eye.
Indications: Treatment of open angle glaucoma or ocular hypertension.
Dosage: Instill one drop of latanaprost ophthalmic solution into the affected eye(s) once daily preferably in the evening.
Use with caution in patients with/during:
  1. Aphakic patients, pseudophakic patients with a torn posterior lens capsule, and patients with known risk factors for macular edema.
  2. Iritis
  3. Renal or hepatic impairment.
  4. Closed angle glaucoma, neovascular glaucoma or inflammatory glaucoma.
  5. Pregnancy, breast feeding or in children.
Side effects:
Common
  • Foreign body sensation
  • Blurred vision
  • Punctate epithelial keratopathy (a disease of the cornea)
  • Increased pigmentation of the iris
  • Itching
  • Conjunctival hyperemia (increased amount of blood in the conjunctiva)
  • Burning
  • Stinging

Life-Threatening Symptoms

  • None expected
Less Common to Rare
  • Lid erythema (redness of the eyelids due to blood vessel dilation)
  • Chest pain
  • Conjunctivitis (inflammation of the conjunctiva)
  • Vitreous hemorrhage from diabetic retinopathy (bleeding in the posterior chamber of the eye to a degenerative disease of the retina caused by diabetes)
  • Diplopia (double vision)
  • Discharge from the eye.
  • Dry eye
  • Excessive tearing
  • Eye pain
  • Lid pain
  • Lid edema (swelling of the eyelids due to fluid accumulation)
  • Change in eye color or eyelashes
  • Upper respiratory tract infection
  • Retinal detachment (the separation between the sensory retina and the retinal pigment epithelium)
  • Muscle pain
  • Photophobia (sensitivity to light)
  • Rash
  • Retinal artery embolus (a plug or blockade in the retinal artery)
  • Lid crusting
Notes: This medication should be refrigerated.

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URL: http://www.opt.indiana.edu/clinics/pteduc/glaucoma/meds/xalatan.htm
Revised: March 19, 2002
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Page design and coding: Terri Greene
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