Postdoctoral Fellows and Research Associates in Vision Science Barry Cense

Barry Cense received his Bachelor of Science degree in applied physics from the Hogeschool Eindhoven (Eindhoven, the Netherlands). He then worked for six years with Philips Corporate Research in Eindhoven, the Netherlands. In March 2001 he moved to Boston (MA) and worked at the Wellman Center for Photomedicine, Massachusetts General Hospital towards his doctorate (Twente University, the Netherlands, 2005 [link to thesis]). In 2005 he joined Don Miller's lab at Indiana University School of Optometry as a Research Associate.

Barry Cense's research interests are in retinal imaging, optical coherence tomography, polarization-sensitive imaging and adaptive optics. In his current project he combines adaptive optics with polarization-sensitive optical coherence tomography. The small speckle size and high lateral resolution that can be achieved with adaptive optics allow us to investigate the polarizing properties of the human retina at a micrometer scale (3 x 3 x 5 μm). For instance, the birefringence of individual retinal nerve fiber bundles may be resolved with this technology. The disease process behind glaucoma, a disease affecting retinal nerve fiber layer tissue, is still not understood. Fundamental research on the distribution of nerve fibers in bundles (which can be characterized by their birefringence) may help us in understanding this process.

Publications

• M.C. Pierce, B.H. Park, B. Cense, and J.F. de Boer. "Simultaneous intensity, birefringence, and flow measurements with high-speed fiber-based optical coherence tomography," Optics Letters 27 (17), 1501-1572, (2002).
• B. Cense, T.C. Chen, B.H. Park, M.C. Pierce, and J.F. de Boer. "In-vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography," Optics Letters, 27 (18), 1610-1612, (2002).
• B.H. Park, M.C. Pierce, B.Cense, and J.F. de Boer. "Real-time multi-functional optical coherence tomography," Optics Express, 11, 782-793, (2003).
• J.F. de Boer, B. Cense, B.H. Park, M.C. Pierce, G.J. Tearney, and B.E. Bouma. "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Optics Letters, 28(21), 2067-2069, (2003).
• B.R. White, M.C. Pierce, N. Nassif, B. Cense, B.H. Park, G.J. Tearney, B.E. Bouma, T.C. Chen, and J.F. de Boer. "In-vivo dynamic human retinal blood flow imaging using ultra-high-speed spectral domain optical Doppler tomography," Optics Express, 11(25), 3490-3497, (2003).
• B. Cense, T.C. Chen, B.H. Park, M.C. Pierce, and J.F. de Boer. "In-vivo birefringence and thickness measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography," Journal of Biomedical Optics, 9(1), 121-125, (2004).
• N. Nassif*, B. Cense*, B.H. Park, S.H. Yun, T.C. Chen, B.E. Bouma, G.J. Tearney, and J.F. de Boer. "In-vivo human retinal imaging by ultra high-speed spectral domain optical coherence tomography," Optics Letters, 29(5), 480-482, (2004).
• N.A. Nassif, B. Cense, B.H. Park, M.C. pierce, S.H. Yun, T.C. Chen, B.E. Bouma, G.J. Tearney, and J.F. de Boer. "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Optics Express, 12(3), 367-376, (2004).
• M.C. Pierce, J. Strasswimmer, B.H. Park, B. Cense, J.F. de Boer. "Birefringence measurements in human skin using polarization-sensitive optical coherence tomography," Journal of Biomedical Optics, 9 (2): 287-291 (2004).
• B. Cense, N.A. Nassif, T.C. Chen, M.C. Pierce, S. Yun, B.H. Park, B.E. Bouma, G.J. Tearney, and J.F. de Boer. "Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography," Optics Express, 12, 2435-2447 (2004).
• B. Cense, T.C. Chen, B.H. Park, M.C. Pierce, and J.F. de Boer. "Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization sensitive optical coherence tomography," Investigative Ophthalmology & Visual Science, 45(8), 2606-2612 (2004).
• M.C. Pierce, R.L. Sheridan, B.H. Park, B. Cense, and J.F. de Boer. "Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomography," Burns, 30, 511Ð517 (2004).
• N.V. Iftimia, B.E. Bouma, J.F. de Boer, B.H. Park, B. Cense, and G.J. Tearney. "Adaptive ranging for optical coherence tomography," Optics Express, 12, 4025-4034 (2004).
• B.H. Park, M.C. Pierce, B. Cense, and J.F. de Boer, "Jones matrix analysis for a polarization-sensitive optical coherence tomography system using fiber-optic components," Optics Letters, 29, 2512-2514 (2004).
• M.C. Pierce, J. Strasswimmer, B.H. Park, B. Cense, and J.F. de Boer, "Advances in Optical Coherence Tomography Imaging for Dermatology," Journal of Investigative Dermatology, 123(3), 458-463 (2004).
• C. Joo, T. Akkin, B. Cense, B. H. Park and J. F. de Boer, "Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imaging." Optics Letters, 30(16), 2131-2133 (2005).
• B.H. Park, M. C. Pierce, B. Cense, S. H. Yun, M. Mujat, G. J. Tearney, B. E. Bouma and J. F. de Boer, "Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 mm." Optics Express, 13(11), 3931-3944 (2005).
• B.H. Park., M. C. Pierce, B. Cense and J. F. de Boer, "Optic axis determination accuracy for fiber-based polarization-sensitive optical coherence tomography." Optics Letters, 30(19), 2587-2589 (2005).
• M. Mujat, R. C. Chan, B. Cense, B. H. Park, C. Joo, T. Akkin, T. C. Chen, and J. F. de Boer, "Retinal nerve fiber layer thickness map determined from optical coherence tomography images," Optics Express, 13, 9480-9491 (2005).
• T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, and J.F. de Boer, "Spectral domain optical coherence tomography - Ultra-high speed, ultra-high resolution ophthalmic imaging," Archives of Ophthalmology, 123(12), 1715-1720, (2005).
• T. C. Chen, B. Cense, J. W. Miller, P.A.D. Rubin., D.G. Deschler, E.S. Gragoudas, and J.F. de Boer, "Histologic Correlation of In Vivo Optical Coherence Tomography Images of the Human Retina," American Journal of Ophthalmology, 141(6), 1165-1168 (2006).
• Y. Zhang, B. Cense, J. Rha, R. S. Jonnal, W. Gao, R. J. Zawadzki, J. S. Werner, S. Jones, S. Olivier, and D. T. Miller, "High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography," Optics Express, 14, 4380-4394 (2006).
• B. Cense, M. Mujat, T. C. Chen, B. H. Park, and J. F. de Boer, "Polarization-sensitive spectral-domain optical coherence tomography using a single line scan camera," Optics Express, 15, 2421-2431 (2007).
• M. Mujat, B.H. Park, B. Cense, T.C. Chen, and J.F. de Boer, "Auto-calibration of spectral-domain optical coherence tomography spectrometers for in-vivo quantitative retinal nerve fiber layer birefringence determination," Journal of Biomedical Optics, 12, 041205 (2007).
• R.S. Jonnal, J. Rha, Y. Zhang, B. Cense, W. Gao, and D.T. Miller, "In vivo functional imaging of human cone photoreceptors," Optics Express, 15, 19 (2007).